张家禹，博士，东莞理工学院生态环境工程技术研发中心副研究员。主要研究方向包括新污染物的生物转化过程与机理研究、抗生素耐药机制研究、以多组学为核心的微生物组学研究，主持包括国家自然科学基金-青年基金项目等科研课题4项，已发表学术论文35篇，其中以第一作者/共同一作/通讯作者发表SCI论文15篇（均发表于中科院一区期刊），授权发明专利2项。

教育经历

2009.09-2013.06，辽宁大学，生物化学与分子生物学，理学学士

2013.09-2016.06，中国农业科学院，生物化学与分子生物学，理学硕士

2016.09-2020.10，清华大学，环境科学与工程，工学博士

工作经历

2020.12-2023.03，清华大学深圳国际研究生院，博士后

2023.03-至今，东莞理工学院，副研究员

教学信息

共同讲授研究生课程《有机污染化学》

科研项目

[1] 国家自然科学基金委员会，青年项目，22206107，典型生物可降解塑料的自然降解过程解译及其表面微生物组全谱表征，2023-01至2025-12，在研，    主持

[2] 广东省基础与应用基础研究基金，粤莞联合基金-地区培育项目，24202107190000690，多界微生物驱动的鲜鱼腐败机理研究及绿色防控技术开发，2025-1至2027-12，在研，主持人

[3] 中国博士后基金会，面上项目，2021M691772，联合应用多维组学和计算化学解译抗生素好氧和厌氧生物降解机理，2021-04至2022-12，结题，主持

教学成果

代表性学术论文（¹共同一作，^*通讯作者）：

[1] Jiayu Zhang^*, Bing Li, Zehan Shen, Zuowu Zhang, Jie Feng, Jonathan W C Wong^*. Antibiotic resistance patterns and cross-family ARG transfer in families Burkholderiaceae and Sphingomonadaceae: A large-scale genome-wide analysis of over 10 K genomes. Journal of Hazardous Materials, 2025, 494, 138642.

[2] Jiayu Zhang, Huaxin Lei, Jin Huang, Jonathan W C Wong, Bing Li^*. Co-occurrence and co-expression of antibiotic, biocide, and metal resistance genes with mobile genetic elements in microbial communities subjected to long-term antibiotic pressure: Novel insights from metagenomics and metatranscriptomics. Journal of Hazardous Materials, 2025, 489, 137559.

[3] Jiayu Zhang, Aixi Tang, Tao Jin, Deshou Sun, Fangliang Guo, Huaxin Lei, Lin Lin, Shu Wensheng, Yu Pingfeng, Xiaoyan Li, Bing Li^*. A panoramic view of the virosphere in three wastewater treatment plants by integrating viral-like particle-concentrated and traditional non-concentrated metagenomic approaches. iMeta, 2024, e188.（封面文章）

[4] Jiayu Zhang, Xiaoyan Li, Uli Klümper, Huaxin Lei, Thomas U. Berendonk, Fangliang Guo, Ke Yu, Chao Yang, Bing Li^*. Deciphering chloramphenicol biotransformation mechanisms and microbial interactions via integrated multi-omics and cultivation-dependent approaches. Microbiome, 2022, 10(1): 180.

[5] Jiayu Zhang^#, Fangliang Guo^#, Hebin Liang, Ke Yu, Wan Cai, Lin Lin, Xiaoyan Li, Bing Li^*. Unraveling metabolic fate of a veterinary antibiotic thiamphenicol via the multi-omic approach. Chemical Engineering Journal, 2024, 484,149592.

[6] Jiayu Zhang^#, Chao Yang^#, Jiahui Hu, Yiting Zhang, Yuezheng Lai, Hongri Gong, Fangliang Guo, Xiaoyan Li, Lin Ye, Bing Li^*. Deciphering a novel chloramphenicols resistance mechanism: Oxidative inactivation of the propanediol pharmacophore. Water Research, 2022, 225: 119127.

[7] Jiayu Zhang^#, Jie Xu^#, Huaxin Lei, Hebin Liang, Xiaoyan Li, Bing Li^*. The development of variation-based rifampicin resistance in Staphylococcus aureus deciphered through genomic and transcriptomic study. Journal of Hazardous Materials, 2023, 442: 130112.

[8] Jiayu Zhang^#, Wenhui Gan^#, Renxin Zhao, Ke Yu, Huaxin Lei, Ruiyang Li, Xiaoyan Li, Bing Li^*. Chloramphenicol biodegradation by enriched bacterial consortia and isolated strain Sphingomonas sp. CL5.1: The reconstruction of a novel biodegradation pathway. Water Research, 2020, 187:116397.

[9] Jiayu Zhang, Xiaoyan Li, Huaxin Lei, Renxin Zhao, Wenhui Gan, Kaiyan Zhou, Bing Li^*. New insights into thiamphenicol biodegradation mechanism by Sphingomonas sp. CL5.1 deciphered through metabolic and proteomic analysis. Journal of Hazardous Materials, 2022, 426: 128101.

[10] Jiayu Zhang, Renxin Zhao, Lijia Cao, Yusha Lei, Jie Liu, Jie Feng, Wenjie Fu, Xiaoyan Li, Bing Li^*. High-efficiency biodegradation of chloramphenicol by enriched bacterial consortia: kinetics study and bacterial community characterization. Journal of Hazardous Materials, 2020, 384:121344.

[11] Jiayu Zhang, Kaiyan Zhou, Fangliang Guo, Huaxin Lei, Renxin Zhao, Lin Lin, Xiaoyan Li, Bing Li^*. The Successional Pattern of Microbial Communities and Critical Genes of Consortia Subsisting on Chloramphenicol and Its Metabolites Through Long-Term Domestication. Engineering, 2023, 31: 59-69.

[12] Zuohong Chen^#, Jiayu Zhang^#, Lin Lin, Yingfei Sun, Xiao-Yan Li, Bing Li^*. Enhanced fermentation for lactic acid production from food waste via hydrothermal pretreatment: performance evaluation and metagenomic analysis. Bioresource Technology, 2025, 440, 133456. （共同一作）

[13] Huaxin Lei^#, Jiayu Zhang^#, Jin Huang, Dengjin Shen, Yin Li, Rui Jiao, Renxin Zhao, Xiaoyan Li, Lin Lin, Bing Li^*. New insights into lincomycin biodegradation by Conexibacter sp. LD01: Genomics characterization, biodegradation kinetics and pathways. Journal of Hazardous Materials, 2023, 441: 129824. （共同一作）

[14] Lijia Cao^#, Jiayu Zhang^#, Renxin Zhao, Yu Deng, Jie Liu, Fu Wenjie, Yusha Lei, Tong Zhang, Xiaoyan Li, Bing Li^*. Genomic characterization, kinetics and pathways of sulfamethazine biodegradation by Paenarthrobacter sp. A01. Environment International, 2019, 131:104961. （共同一作）

[15] Jiayu Zhang, Lili Liu, Lei Ren, Weimin Feng, Peng Lv, Wei Wu, Yanchun Yan^*. The single and joint toxicity effects of chlorpyrifos and beta-cypermethrin in zebrafish (Danio rerio) early life stages. Journal of Hazardous Materials, 2017, 334:121-131.